Superagers Have Different Brains; Suicidality and Seizures; Brain Prize Winners

The brains of superagers — adults over age 80 with extraordinary memory capacity — were strong producers of new neurons, showing a distinct profile of hippocampal neurogenesis in a post-mortem study. (Nature)

Longitudinal Epstein-Barr virus-specific antibody levels helped distinguish multiple sclerosis (MS) from other neuroinflammatory diseases in a cohort study. (JAMA Neurology)

Accelerometry data documented daytime activity patterns that preceded clinical disability worsening and brain atrophy in a cohort of people with relapsing or progressive MS. (Neurology)

Irregular sleep patterns were associated with higher Alzheimer’s pathological burden and faster amyloid accumulation in cognitively unimpaired older adults at risk for Alzheimer’s disease, data from the PREVENT AD cohort showed. (Alzheimer’s & Dementia)

HHS postponed the Interagency Autism Coordinating Committee (IACC) meeting scheduled for March 19, days after autism researchers launched an independent committee to meet the same day.

Suicidality at the time of focal epilepsy diagnosis correlated with future drug resistance, prospective data from the Human Epilepsy Project showed. (JAMA Neurology)

In a cohort of cognitively unimpaired older women, plasma phosphorylated tau 217 (p-tau217) was associated with incident mild cognitive impairment or dementia up to 25 years later. (JAMA Network Open)

Sumitomo Pharma said it obtained conditional approval in Japan to manufacture and market raguneprocel, a stem cell treatment for motor symptoms in Parkinson’s patients who had an inadequate response to therapies like levodopa.

David Ginty, PhD, of Harvard University in Boston, and Patrik Ernfors, PhD, of the Karolinska Institutet in Stockholm, will share the 2026 Brain Prize from the Lundbeck Foundation, worth about $1.6 million. (The Transmitter)