Warning Signs in Young-Onset CRC Data; Rifaximin Drift in Cirrhosis; Neonatal Hep C

Among French patients under 40 with early-onset colorectal cancer (CRC), the incidence of multiple-site metastases increased by 10% annually from 2004 to 2021, and no survival gains were observed for those with peritoneal involvement during the study period, researchers reported in JAMA Network Open.

A text-messaging strategy in a safety-net population topped nurse-led telephone outreach for getting patients to complete fecal immunochemical testing in a timely manner. (JAMA Network Open)

Expert endoscopists can take their pick between slim or adult colonoscopes for non-difficult colonoscopies in patients with obesity, the randomized PACE trial indicated. (American Journal of Gastroenterology)

In an effort to reduce colectomy for nonmalignant polyps, researchers showed that endoscopic submucosal dissection can be effectively introduced in community hospitals. (Gastro Hep Advances)

Achalasia was independently associated with a risk for esophageal squamous cell carcinoma but not esophageal adenocarcinoma, according to a population-based study of Nordic countries. (Gastroenterology)

Fecal microbiota transplant for patients with persistent multidrug-resistant organisms (MRDOs) did not lead to lower rates of MRDOs or decrease the abundance of antimicrobial resistance genes, a trial from India found. (JAMA Internal Medicine)

A randomized trial found that rifaximin and a low FODMAP diet resulted in similar symptom improvement for patients with irritable bowel syndrome with diarrhea. (Clinical Gastroenterology and Hepatology)

Meanwhile, experts argued that the expanding use of rifaximin in cirrhosis has outpaced the evidence and called for antimicrobial stewardship principles in guidelines. (Lancet Gastroenterology & Hepatology)

Researchers linked low vitamin B6 levels to worse outcomes among patients with primary sclerosing cholangitis in the U.S. and abroad. (Journal of Hepatology)

Nearly one in five pregnant women screened in the second trimester had steatotic liver disease, with associations observed for gestational hypertension or diabetes, very preterm delivery, and babies born small for gestational age. (Clinical Gastroenterology and Hepatology)

Only 42% of children perinatally exposed to hepatitis C virus were tested, and even fewer of those eligible got treatment for the virus, a cohort study from Massachusetts found. (JAMA Network Open)

Three-year follow-up data from a randomized trial backed the use of a funnel-shaped intra-abdominal mesh for preventing parastomal hernia after permanent colostomy. (JAMA Surgery)

Roughly one in 17 patients with Crohn’s ileitis who undergo primary ileocolic resection will require more surgery within 5 years, according to a systematic review and meta-analysis. (Inflammatory Bowel Diseases)