Synthetic biology may finally be ready to solve life’s biggest mystery

A living organism is made from components that aren’t themselves living. This simple statement has profound implications. For one, it means that there is no mystical force that animates us and other life forms. For another, it means that it should be possible to build a life form from scratch – and we are now a step closer to doing so.

Artificial life has been the guiding light of synthetic biology for some time. In 2010, biologists at the J. Craig Venter Institute in California synthesised the stripped-down genome of a bacterium and inserted it into the chassis of another cell, emptied of its own DNA. The resulting organism, with a record-low number of genes (473) was able to grow and reproduce. But even then, scientists didn’t understand what a third of those genes were doing, or whether they were even needed. Instead of rebooting an existing cell with a synthetic genome, we need to build an organism from the ground up.

That is what scientists at the University of Missouri are now attempting. The SpudCell – named both to evoke Sputnik and the dawn of the space age, and for its resemblance to a potato – is an entity based on just 36 genes. It self-assembled when the genes were supplied with all the building blocks necessary for life, forming cell-like bubbles and making proteins.

But that’s it. The SpudCell can only make proteins because it is supplied with ribosomes, the crucial cell components that make proteins. It can’t metabolise food, supply itself with energy or reliably divide and reproduce. It isn’t alive, and it needs intensive care just to perform its basic functions. Nevertheless, the SpudCell represents a significant breakthrough in the creation of artificial life. If a modern living cell is a jet airliner, the SpudCell is the rickety wooden-and-cotton proto-airplane made by the Wright brothers.

Better versions will soon follow, with potentially transformative applications. The hope is that synthetic cells will one day be able to supply materials that are currently derived from fossil fuels, such as plastics, fuels and fertiliser. That is keenly needed. But the work in understanding how a living entity operates will shed light on what life needs, and how it emerges from dead materials. If we crack this ultimate mystery, synthetic biology will have really delivered.