6% of Seniors Depressed; ADHD and Hormones; Novel Antipsychotic Eases Schizophrenia

A study of older adults showed that 6% had depression, with higher prevalences in certain groups, including women, those who were unmarried, and those with chronic medical conditions. (Journal of the American Geriatrics Society)

A single 25-mg dose of synthetic psilocybin significantly improved depressive symptoms by week 3 among participants with severe treatment resistance in a small single-arm open-label trial. (American Journal of Psychiatry)

Older adults with major depressive disorder displayed riskier driving behaviors compared with those without depression, according to a prospective longitudinal cohort study. (JAMA Network Open)

Navacaprant, an investigational kappa opioid receptor antagonist, was no better than placebo for alleviating depression symptoms in the phase III KOASTAL-1 study, said developer Neumora.

Symptoms of attention deficit-hyperactivity disorder (ADHD) may fluctuate along with hormonal shifts, a study suggested. (Scientific American)

Prenatal exposure to systemic glucocorticoids was tied to an increased risk of some mental disorders, a large cohort study of Danish infants showed. (JAMA Network Open)

Individuals ineligible for ADHD medication trials may face higher risks of adverse outcomes, such as higher rates of psychiatric hospitalizations and specialist care visits related to substance use disorder, depression, and anxiety, according to a Swedish population-based study. (Lancet Psychiatry)

Investigational LB-102 — a potential first-in-class benzamide antipsychotic — significantly improved schizophrenia symptoms after 4 weeks with all three doses tested in a phase II trial, said LB Pharmaceuticals.

A patient was reportedly violently attacked by two fellow patients at Maryland’s Clifton T. Perkins Hospital Center, a maximum-security forensic psychiatric facility. (Washington Post)

Mothers treated with selective serotonin reuptake inhibitors tended to have lower protein levels in breast milk that could have health risks for infants, a cross-sectional study suggested. (JAMA Network Open)

Here’s what social media is like for people with Alzheimer’s disease or dementia. (The Atlantic)