Acromegaly Injectable Rejected; Nobel Prize Winner Dies; Obesity Doubles in Kids

The FDA declined to approve investigational octreotide (CAM2029) extended-release injection for acromegaly, said developer Camurus, citing facility-related deficiencies identified during an inspection of a third-party manufacturer.

Paternal use of metformin for type 2 diabetes during sperm development wasn’t tied with congenital malformations in offspring, a study of over 3 million pregnancies found. (The BMJ)

In a phase III trial of adults with type 2 diabetes with heart disease and/or chronic kidney disease, oral semaglutide (Rybelsus) adjunctive to standard of care reduced the risk of major adverse cardiovascular events by 14% versus placebo, Novo Nordisk said.

Endocrinologist Andrew V. Schally, PhD — who won a Nobel Prize for discovering the hormones used by the brain to control growth, reproduction, and other bodily functions — passed away at age 97. (New York Times)

Eating a low-carb diet for 12 weeks had beneficial effects on β-cell function in adults with mild type 2 diabetes. (Journal of Clinical Endocrinology & Metabolism)

Prevalence of obesity and severe obesity in the U.S. has nearly doubled over the past two decades among people ages 2-19 years, with current rates reaching 21% and 7%, respectively. (Morbidity and Mortality Weekly Report)

Eli Lilly filed suit against three medical spas and online vendors for selling products claiming to contain tirzepatide (Zepbound). (Reuters)

The Endocrine Society and Keystone Symposia announced they will jointly host a series of three conferences — slated to launch in late 2026 or early 2027 and set to run for at least 3 years — to advance endocrine research.

Adults with a history of opioid use disorder or alcohol use disorder on a GIP and/or GLP-1 receptor agonist for type 2 diabetes and obesity had significantly lower rates of opioid overdose and alcohol intoxication. (Addiction)

Texas is suing a doctor for allegedly violating state restrictions on gender-affirming care for minors. (NBC News)

People with type 1 diabetes who ate more whole food plant-based meals spent more time in target glucose range, a study in Journal of Clinical Endocrinology & Metabolism found.

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