Alzheimer’s-Autism Links; Early-Onset Dementia Risks; CAR-T for MS?

Recently established links between autism and Alzheimer’s disease could influence the way both disorders are treated. (Washington Post)

The apolipoprotein E mimetic peptide CN-105, which is being studied to reduce postsurgical neuroinflammation and delirium, was safe and feasible in a phase II trial of older adults. (JAMA Network Open)

Pooled data from five U.K. and U.S. longitudinal cohort studies showed that male sex, Black race, low education, diabetes, obesity, depression, alcohol overconsumption, smoking, and physical inactivity were independently associated with early-onset dementia. (Lancet Healthy Longevity)

BBC Science Focus took a closer look at limbic-predominant age-related TDP-43 encephalopathy.

A case series documented that interstitial lung disease emerged in six multiple sclerosis (MS) patients treated with ocrelizumab (Ocrevus). (JAMA Neurology)

Payments to clinicians were tied to higher brand-name prescribing for two MS drugs — glatiramer (Copaxone) and dimethyl fumarate (Tecfidera) — in a cross-sectional study of Medicare patients. (Neurology)

Can chimeric antigen receptor (CAR) T-cell therapy improve symptoms in people with MS? (NBC News)

A secondary analysis of data from the STARSHIP study indicated that sustained elevations of intracranial pressure above 14 to 15 mm Hg were tied to poor long-term outcomes in pediatric patients with traumatic brain injury. (JAMA Pediatrics)

The Transmitter published an excerpt from “The Brain, In Theory,” a new book from neuroscientist Romain Brette, PhD.

Rebecca King Crews, wife of “America’s Got Talent” host Terry Crews, said she was treated with focused ultrasound for Parkinson’s disease. (NBC)

A post-mortem exam revealed that former New Zealand rugby player and brain injury activist Shane Christie, who died by suspected suicide in 2025, had advanced chronic traumatic encephalopathy. (AP)