Alzheimer’s-Heparin Link; Two Phases of Alzheimer’s Damage; Prion Disease Testing

Heparin treatment was associated with a delayed diagnosis of Alzheimer’s dementia, electronic health records in two U.S. health systems showed. (Molecular Psychiatry)

Analyses of cell types after death suggested that Alzheimer’s disease damages the brain in two distinct phases. (Nature Neuroscience)

Smartphone data collected during a brief task helped identify subtle changes in people with subjective cognitive decline who had a higher risk of developing dementia. (PLOS Digital Health)

Older adults diagnosed with dementia were almost twice as likely to migrate to another county or state compared with those diagnosed with myocardial infarction, chronic obstructive pulmonary disease, or colon cancer. (JAMA Network Open)

Denali Therapeutics said its partner Sanofi stopped its phase II multiple sclerosis trial of investigational oditrasertib after the drug failed to meet primary and secondary endpoints. (Reuters)

The FDA granted clearance to proceed with phase III studies of buntanetap in people with early Alzheimer’s disease, Annovis said.

Multisite skin biopsies were superior to cerebrospinal fluid samples to diagnose prion diseases. (JAMA Neurology)

The timing of learning a second language altered brain functional organization at both global and local levels, functional MRI showed. (Communications Biology)

A new American Heart Association statement explored the mechanisms that link cardiac disease and cognitive impairment. (Stroke)