Ancient DNA May Fuel Cancer; ASCO Appeals to Oncologists; Pesticide Cancer Risk

Flecks of leftover ancient viral DNA intertwined with the genetics of modern humans may help cancer survive. (U.S. News & World Report)

The Centers for Medicare and Medicaid Services’ interpretation of the Inflation Reduction Act’s drug price negotiation authority may delay access to promising therapies, the president of Severn Health Solutions argued. (STAT)

A New Jersey judge refused to disqualify key opponents of Johnson & Johnson’s bankruptcy plan to resolve lawsuits stemming from the company’s talc products. (Reuters)

The American Society of Clinical Oncology (ASCO) appealed to oncologists to share their personal stories about drug shortages and the importance of federal support for cancer research as Congress prepares to act on legislation that could affect patients and providers for years to come.

MAIA Biotechnology announced positive results from the first patients with non-small cell lung cancer treated with its telomere-targeting therapy THIO followed by the PD-1 inhibitor cemiplimab (Libtayo).

The FDA issued draft guidance for how manufacturers should report post-approval manufacturing changes for biosimilars and interchangeable products.

The agency also issued final guidance for use of real-world data in regulatory submissions.

Jaguar Health announced that a phase III trial of crofelemer (Mytesi) did not meet the primary endpoint for diarrhea prophylaxis across multiple types of solid tumors.

Two reduced-dose strategies for radiopharmaceutical products to treat metastatic castration-resistant prostate cancer worked as well as standard dosing but with less toxicity. (Society of Nuclear Medicine and Molecular Imaging)

Does exposure to pesticides pose a greater cancer risk than smoking? (Frontiers in Cancer Control and Society)

Principal toxicities associated with CAR T-cell therapy rarely occur after the first 2 weeks, creating a potential to reduce the FDA-mandated monitoring period by half. (Blood Advances)

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