Antipsychotics Compared; Psychiatrist’s Research Misconduct; Teen Suicide Predictor

Not all antipsychotics for schizophrenia spectrum disorder were equally effective for relapse prevention in a large comparative effectiveness study, with quetiapine performing the worst. (JAMA Network Open)

In a small study of patients with bipolar depression, 39% achieved clinical response following 4 weeks of intravenous ketamine or intranasal esketamine (Spravato) while 13% achieved remission. (Journal of Clinical Psychiatry)

This may help explain why people with schizophrenia hear voices. (STAT)

Former Columbia University psychiatrist Bret Rutherford, MD, committed research misconduct by “falsely reporting that all human research subjects met the inclusion/exclusion criteria for late-life depression studies,” according to the U.S. Office of Research Integrity.

The Texas Medical Board temporarily suspended psychiatrist Astik Joshi, MD, for reportedly failing to sign up for alcohol and drug testing. (Lubbock Avalanche-Journal)

In pregnant women with depression or anxiety but without severe psychiatric conditions, discontinuation of selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors during pregnancy was not associated with adverse psychiatric outcomes up to 18 months after childbirth. (JAMA Network Open)

The Lancet Psychiatry Commission published its report on mental health in Ukraine.

Some teens and young women on X (formerly Twitter) said they were shown posts encouraging eating disorders. (NBC News)

The Patient Health Questionnaire-9 (PHQ-9) modified for teens was better at predicting youth suicide attempts compared with the original PHQ-9, and could be considered for screening during outpatient visits, researchers suggested in JAMA Network Open.

Aerobic physical activity was associated with reduced depression in cancer patients, a meta-analysis found. (JAMA Network Open)

Investigational dalzanemdor failed to improve cognition compared with placebo in a phase II study of early Alzheimer’s disease, Sage Therapeutics said.

Here’s what some Yale University psychiatrists think of the newly approved schizophrenia drug xanomeline and trospium chloride (Cobenfy). (Yale Daily News)

Nearly one-fourth of LGBTQ+ women have attempted suicide, and two-thirds have sought treatment for trauma, a survey found. (NPR)

The CDC’s 2023 Youth Behavioral Risk Survey showed that 40% of adolescents had persistent feelings of sadness or hopelessness and 20% had seriously considered suicide. (Morbidity and Mortality Weekly Report)

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