Brain Training and Memory Decline; Alzheimer’s Pioneer Dies; Notorious APOE4

In a 5-year follow-up study, cognitive training reduced memory decline in people with mild cognitive impairment. (Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring)

Subcutaneous ocrelizumab and hyaluronidase (Ocrevus Zunovo) was approved for relapsing and progressive multiple sclerosis, Genentech said. The OCARINA II study supported the FDA’s decision.

Erenumab (Aimovig) induced remission of non-opioid medication overuse headache in chronic migraine patients. (JAMA Neurology)

Metformin led to less brain aging in male monkeys. (Cell)

Neurologist and research pioneer Francisco Lopera, MD, who identified the world’s largest extended family with Alzheimer’s disease, died of cancer in Medellin, Colombia. (AlzForum)

Science looked at the notorious APOE4 gene.

Alzheimer’s disease, frontotemporal dementia, and progressive supranuclear palsy had 32 shared disease-associated cell types. (Cell)

Investigational VO659 reduced mutant huntingtin protein in cerebrospinal fluid in an early Huntington’s disease study, according to Vico Therapeutics.

Concomitant Lewy body pathology exacerbated cognitive decline in Alzheimer’s disease. (Nature Communications)

Blocking excessive mitochondrial fission prevented chronic neurodegeneration after traumatic brain injury in mice. (Cell Reports Medicine)

Some NFL players are wearing soft-shelled pads called Guardian Caps over their helmets during games this season. (ESPN)

More research linked air pollution with Parkinson’s disease risk. (JAMA Network Open)