Fast-Acting Novel Depression Tx; Lumryz Label Expanded; GLP-1s for Addiction?

As an adjunctive treatment to antidepressants, investigational SPN-820 — a novel, first-in-class intracellular modulator of mTORC1 that was developed to provide a rapid-onset response — was safe and effective in adults with major depressive disorder in a phase IIa study, said Supernus Pharmaceuticals.

Risk of sudden cardiac death was 4.5-fold higher among patients with schizophrenic disorders compared with the general population, a Danish study found. (Heart)

The FDA expanded the approval of sodium oxybate (Lumryz) for cataplexy or excessive daytime sleepiness to include children with narcolepsy ages 7 years and up, Avadel Pharmaceuticals announced.

Eight distinct forms of traumatic and adverse childhood experiences moderated developmental changes in psychiatric risk and cognitive ability in different ways, according to a cohort study of kids. (JAMA Psychiatry)

Experts share why mental illness may raise the risk of severe outcomes from COVID. (New York Times)

Adults with a history of opioid use disorder or alcohol use disorder on a GIP and/or GLP-1 receptor agonist for type 2 diabetes or obesity had significantly lower rates of opioid overdose and alcohol intoxication in a real-world analysis. (Addiction)

After the FDA rejected Lykos Therapeutics’ MDMA-assisted post-traumatic stress disorder therapy in August, the company said it is planning an additional phase III trial and a potential independent third-party review of prior phase III clinical data following a recent meeting with the agency.

A psychiatrist who helped write the 1973 “Goldwater rule” that kept many experts from commenting on the mental health of political figures said he would recommend dementia tests for Republican presidential nominee Donald Trump. (HuffPost)

A retrospective study suggested that maternal prenatal cannabis use around 8 to 10 weeks’ gestation was not linked to child autism spectrum disorder. (JAMA Network Open)

More than 2,400 Kaiser Permanente mental health workers went on strike in Southern California, citing increased workloads and staffing shortages. (AP)

People with major depressive disorder showed improvements in depression scores after 10 weeks of home-based transcranial direct current stimulation in a randomized phase II trial. (Nature Medicine)

A Lancet Psychiatry Commission was announced with the goal of offering evidence-based recommendations to limit the harms of problematic internet usage.

The Federal Communications Commission voted to require that all calls to the 988 Suicide and Crisis Lifeline be routed by geolocation. (Roll Call)

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