Gas-X Recall; MASLD and Alzheimer’s Mortality; Counties Without a Gastroenterologist

Certain lots of Gas-X Extra Strength gel capsules were recalled over potential contamination with a coolant chemical that could cause nausea or vomiting, stomach pain, and diarrhea, according to an FDA notice.

Researchers found that mutations in GPR15 were linked to severe, early-onset inflammatory bowel disease (IBD). (Nature)

The timing or pattern of food introduction after breast milk or formula was not associated with future IBD development, an analysis of Scandinavian birth cohorts found. (Inflammatory Bowel Diseases)

A French IBD study confirmed the risk of lymphoma with TNF inhibitors and thiopurines, particularly when used in combination. (Clinical Gastroenterology and Hepatology)

New research assuaged concerns about the long-term risks of an isolated periappendiceal red patch in ulcerative colitis. (Inflammatory Bowel Diseases)

Anxiety was linked with a greater likelihood of proton pump inhibitor (PPI) refractoriness in some gastroesophageal reflux disease phenotypes. (Clinical Gastroenterology and Hepatology)

Vitamin E led to significant decreases in liver enzymes in a placebo-controlled trial of patients with metabolic dysfunction-associated steatotic liver disease (MASLD). (Hepatology)

A 30-year cohort study found that non-obese patients with MASLD had a more than threefold higher risk of Alzheimer’s mortality versus MASLD patients with obesity. (Gastro Hep Advances)

In patients with chronic hepatitis B and complete viral suppression, those also achieving hepatitis B surface antigen seroclearance had lower liver cancer risk. (Hepatology)

Could select patients safely stop taking immunosuppressants following a liver transplant? (Clinical Gastroenterology and Hepatology)

A global study of inpatients with cirrhosis showed comorbid chronic kidney disease to be associated with a history of more ascites, an increased risk for in-hospital acute kidney injury, and higher mortality. (Gut)

PPI use prior to a non-cardia gastric cancer diagnosis was not linked to an increased risk of advanced cancer, data from five Nordic countries indicated. (American Journal of Gastroenterology)

Meanwhile, a U.S. study found higher incidence of non-cardia gastric cancer in Hispanic and Asian populations. (Gastro Hep Advances)

One-time colonoscopy and sustained biennial fecal immunochemical testing showed nonsignificant differences for 10-year risks of colorectal cancer (CRC) incidence and mortality, post-hoc data from a randomized trial found. (Gut)

A cross-sectional study from Texas found that patients diagnosed with younger-onset CRC tended to have longer survival than those diagnosed at an average age of onset. (JAMA Oncology)

Nearly 70% of U.S. counties do not have a gastroenterologist. (American Journal of Gastroenterology)

The self-reported Bristol Stool Form Scale may be unreliable for subtyping irritable bowel syndrome and assessing burden. (American Journal of Gastroenterology)

JAMA published a review on exocrine pancreatic insufficiency.

And a panel of experts issued recommendations on the management and follow-up of percutaneous cholecystostomy drains. (JAMA Network Open)