Genital Crohn’s Disease; Colon Cancer Found in Wastewater; Treating H. Pylori

A case report review examined complications, diagnosis, and treatment of genital Crohn’s disease, a rare extraintestinal manifestation with no standard protocols for management. (Gastro Hep Advances)

In Crohn’s disease and ulcerative colitis, dose escalation of subcutaneous infliximab (Remicade) after loss of response led to response recovery in over 80% of patients, according to post hoc analyses of the LIBERTY trials. (Inflammatory Bowel Diseases)

Intestinal ultrasound scans can help predict first-line therapy failure and need for colectomy in kids with acute severe ulcerative colitis, findings from a prospective multicenter study in Europe found. (Gastroenterology)

A proof-of-concept study suggested that a marker of colorectal cancer (CDH1) can be detected in wastewater and could serve as an early warning system of areas to target screening. (Journal of Epidemiology & Community Health)

Researchers developed and validated a noninvasive clinical-radiologic model to predict prognosis in liver cancer patients following transarterial chemoembolization. (Gut)

The use of metformin was linked with a reduced risk of esophageal cancer in a Nordic case-control study. (JAMA Network Open)

For patients with diabetes, prediabetes, or weight issues, participation in a tailored nutrition-focused telehealth care model was associated with lower risk of steatotic liver disease and advanced liver disease. (Hepatology)

Could a cost-effective, blood-based fibrosis screening pathway using Fibrosis-4 and enhanced liver fibrosis tests make its way into primary care? (Gastro Hep Advances)

Experts in Lancet Gastroenterology & Hepatology reviewed who and how to test for hepatitis D virus, which in people with chronic hepatitis B is associated with rapid progression to liver cirrhosis and high mortality.

Two systematic reviews and meta-analyses in Lancet Gastroenterology & Hepatology looked at the natural history of chronic hepatitis B in untreated adults without cirrhosis and the efficacy of antiviral therapy in adults with chronic hepatitis B according to patients’ baseline viral DNA and alanine aminotransferase levels.

An algorithm for chronic pancreatitis failed to prove significantly better than standard care in terms of pain severity and quality of life, but showed promise for certain subgroups, according to a nationwide cluster randomized trial in the Netherlands. (American Journal of Gastroenterology)

Authors in JAMA reviewed the treatment of Helicobacter pylori infection.