Friday, August 1, 2025
News Health
  • Health News
  • Hair Products
  • Nutrition
    • Weight Loss
  • Sexual Health
  • Skin Care
  • Women’s Health
    • Men’s Health
No Result
View All Result
  • Health News
  • Hair Products
  • Nutrition
    • Weight Loss
  • Sexual Health
  • Skin Care
  • Women’s Health
    • Men’s Health
No Result
View All Result
HealthNews
No Result
View All Result
Home Health News

GLP-1 RAs Linked to Doubled Risk for Macular Degeneration

June 5, 2025
in Health News
Share on FacebookShare on Twitter


TOPLINE:

Patients with diabetes using glucagon-like peptide 1 receptor agonists (GLP-1 RAs) may face more than twice the risk for developing neovascular age-related macular degeneration compared with those not using the medications, data from Canada showed. The risk appears to increase with longer exposure to the drugs.

METHODOLOGY:

  • Researchers conducted a population-based, retrospective cohort study using administrative data for 139,002 patients aged 66 years or older in Ontario, Canada, from January 2020 to November 2023.
  • The researchers matched 46,334 patients who had received a GLP-1 agent (predominantly semaglutide) for at least 6 months 1:2 with patients who had not received this type of medication, based on factors such as age, gender, duration of diabetes, and comorbidities.
  • They examined the incidence of new diagnoses of neovascular age-related macular degeneration during 3 years of follow-up.

TAKEAWAY:

  • Patients exposed to GLP-1 RAs showed a higher incidence of neovascular age-related macular degeneration than unexposed patients (0.2% vs 0.1%).
  • Both unadjusted and adjusted Cox proportional hazard models estimated higher risk for neovascular age-related macular degeneration among patients exposed to GLP-1 medication (hazard ratio [HR], 2.11; 95% CI, 1.58-2.82; adjusted HR, 2.21; 95% CI, 1.65-2.96).
  • In a sensitivity analysis, longer duration of exposure to a GLP-1 RA was associated with increased risk for neovascular age-related macular degeneration.

IN PRACTICE:

“GLP-1 RAs have had a tremendous role in the care of patients with diabetes and now those needing additional help with weight management. However, the adage that ‘there is no such thing as a free lunch’ remains true,” wrote Brian L. VanderBeek, MD, MPH, with the Scheie Eye Institute at the University of Pennsylvania Perelman School of Medicine, Philadelphia, in an editorial accompanying the study. “While certainly not outweighing the good these medications offer, prescribing physicians need to keep in mind the real and serious ocular adverse events that may occur.”

SOURCE:

Rajeev H. Muni, MD, with St. Michael’s Hospital in Toronto, Ontario, was the corresponding author of the study, which was published online on June 5 in JAMA Ophthalmology.

LIMITATIONS:

The analysis did not stratify results by the type of GLP-1 RA prescribed or consider dose, route of administration, or frequency of administration. The researchers had limited information about variables like smoking and sun exposure. “Further research is needed to determine if there is a true cause and effect relationship,” the study authors wrote.

DISCLOSURES:

Some of the researchers have received support from the Silver Target Foundation, the PSI Foundation, and Fighting Blindness Canada. Muni declared consulting for Alcon, Apellis, AbbVie, Bayer, Bausch Health, and Roche. His institution has received financial support from these companies.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.



Source link : https://www.medscape.com/viewarticle/glp-1-ras-linked-doubled-risk-macular-degeneration-2025a1000f7q?src=rss

Author :

Publish date : 2025-06-05 15:00:00

Copyright for syndicated content belongs to the linked Source.

Previous Post

GLP-1 Drugs May Cause Tooth Decay, Experts Say

Next Post

MHRA Urges Contraception With GLP-1 Weight-Loss Drugs

Related Posts

Health News

Preeclampsia Prediction Moving Closer to Reality

August 1, 2025
Health News

‘I Became so Quiet’: When Physicians Attempt Suicide

August 1, 2025
Health News

Why is it so hard to say no?

August 1, 2025
Health News

Cameras that work like our eyes could give boost to astronomers

August 1, 2025
Health News

CRC Risk Lower With Positive FIT and Follow-Up Colonoscopy

August 1, 2025
Health News

Are Caregivers Adequately Prepared to Manage Food Allergies?

August 1, 2025
Load More

Preeclampsia Prediction Moving Closer to Reality

August 1, 2025

‘I Became so Quiet’: When Physicians Attempt Suicide

August 1, 2025

Why is it so hard to say no?

August 1, 2025

Cameras that work like our eyes could give boost to astronomers

August 1, 2025

CRC Risk Lower With Positive FIT and Follow-Up Colonoscopy

August 1, 2025

Are Caregivers Adequately Prepared to Manage Food Allergies?

August 1, 2025

The New Scientist Book Club’s verdict on Lake of Darkness by Adam Roberts: A mixed bag

August 1, 2025

GLP-1 RAs May Up Optic Neuropathy Risk in Seniors With Diabetes

August 1, 2025
Load More

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    

© 2022 NewsHealth.

No Result
View All Result
  • Health News
  • Hair Products
  • Nutrition
    • Weight Loss
  • Sexual Health
  • Skin Care
  • Women’s Health
    • Men’s Health

© 2022 NewsHealth.

Go to mobile version