Hearing Loss-Cognition Link; Circadian Brain Changes; Repetitive Head Impact Markers

The severity of hearing loss in middle age was linked with several domains of cognitive impairment. (JAMA Network Open)

Two Omani siblings who presented with early-onset parkinsonism had a mutation in SGIP1. (Cell Reports Medicine)

An adaptive platform trial showed that neither memantine nor trazodone improved either functional outcome or mortality in motor neuron disease. (Lancet Neurology)

Who should pay for Alzheimer’s blood tests? (JAMA)

Circadian rhythms were tied to changes in global and regional brain morphology in a man who had 40 MRIs and blood tests over a month. (Journal of Neuroscience)

Tavapadon, an investigational D1/D5 dopamine receptor partial agonist, improved scores on the combined part II and III Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) in early Parkinson’s disease, AbbVie announced.

And interim data showed sustained improvements in chorea associated with Huntington’s disease regardless of antipsychotic use, Neurocrine said.

Anti-CD20 drugs did not delay confirmed disability progression in patients with primary progressive multiple sclerosis. (Neurology)

Plasma biomarkers p-tau181, p-tau231, glial fibrillary acidic protein, and neurofilament light may help characterize neuropathologies associated with repetitive head impacts. (Alzheimer’s & Dementia)

The Transmitter looked at the life of the late author Steve Silberman, whose foundational book NeuroTribes: The Legacy of Autism and the Future of Neurodiversity helped shape scientific attitudes about people with autism.