Imcivree Label Expanded; Weight Loss With Weekly Injection; Kidney Donation Chain

The FDA expanded the indication for setmelanotide (Imcivree) to include children as young as 2 years with syndromic or monogenic obesity due to Bardet-Biedl syndrome or genetically confirmed pro-opiomelanocortin, said maker Rhythm Pharmaceuticals.

Among patients with type 2 diabetic nephropathy receiving bremelanotide in the small phase IIb BREAKOUT study, 71% achieved greater than 30% reduction in urine protein to creatinine ratio at 6 months, Palatin Technologies announced.

In a draft recommendation, the U.S. Preventive Services Task Force said that older adults should not take vitamin D and calcium supplements for the primary prevention of falls and fractures.

Even after surgery, patients with Cushing’s syndrome have an altered gut microbiome, “indicating a possible target for additional probiotic interventions to accelerate convergence to a healthy microbiome,” authors of a longitudinal analysis concluded. (Journal of Clinical Endocrinology & Metabolism)

A once-weekly injection consisting of a fixed-dose combination of cagrilintide 2.4 mg and semaglutide 2.4 mg (Wegovy) led to greater weight loss by week 68 compared with either drug alone or placebo in the phase III REDEFINE 1 trial, Novo Nordisk said.

In a cross-sectional survey of midlife female veterans, sexual-minority women self-reported better sexual functioning and fewer effects of vaginal symptoms on sexual function compared with their heterosexual peers. (Menopause)

The Ohio State University Wexner Medical Center Comprehensive Transplant Center set a record-breaking kidney “donation chain,” with 20 surgeries over a 2-day period. (Columbus Dispatch)

People are coming into the doctor’s office for weight-loss drugs — and getting diagnosed with other conditions along the way. (Reuters via Quartz)

Palopegteriparatide (Yorvipath), the only FDA-approved treatment for hypoparathyroidism in adults, is now available in the U.S., said Ascendis Pharma.

Police raided the home of a woman in Medina, Tennessee, finding 300 vials of counterfeit GLP-1 drugs. (NBC News)

For patients wanting to pause their GLP-1 drugs this holiday season, here’s what doctors say they should know. (CNN)

In a JAMA viewpoint, WHO officials noted that the global health systems community “must be mindful that pharmacological intervention alone will be insufficient” to treat obesity, even with the availability of highly effective GLP-1 receptor agonists.

After gender-affirming surgery disappeared in the U.S. for decades, trans patients and advocates are fighting to maintain access to such care. (STAT)

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