Liver Risks in U.S. Diet Guidelines; Sexual Health in IBD; PFAS and Gut Inflammation

Experts warned that components of the new U.S. Dietary Guidelines like red meat intake are associated with greater liver fibrosis risk while liver-protective foods such as beans were not included. (American Journal of Gastroenterology)

Can some chronic hepatitis B patients stop routine liver cancer surveillance if they achieve hepatitis B surface antigen seroclearance? (Gastroenterology)

A bipartisan pair of House lawmakers introduced a bill that aims to end hepatitis C by expanding testing and treatment. (Roll Call)

With a rate of 98.5 per 100,000 individuals, the incidence of alcohol-associated hepatitis in the U.S. topped other nations, according to a systematic review. (Clinical Gastroenterology and Hepatology)

For patients with decompensated cirrhosis and acute kidney injury (AKI), treatment with non-selective beta-blockers at the time of AKI diagnosis was associated with better kidney recovery and lower 28-day mortality, a multicenter study indicated. (Journal of Hepatology)

Research in JAMA Network Open teased out sex-based differences in the causes of death among U.S. men and women with liver cirrhosis.

The investigational FGF21 analogue zalfermin did not improve liver fibrosis in patients with metabolic dysfunction-associated steatohepatitis and clinically significant fibrosis in a placebo-controlled phase II trial. (Lancet Gastroenterology & Hepatology)

Patients with metabolic dysfunction-associated steatotic liver disease and excessive IgA expression represent a high-risk group, according to research in the Journal of Hepatology.

A Nature Communications study suggested that a novel monitoring system that demonstrates how a liver performs in real time during machine perfusion could improve the evaluation of donor livers prior to transplant.

A U.K. study suggested that clinicians could do a better job addressing the sexual health of inflammatory bowel disease (IBD) patients. (Inflammatory Bowel Diseases)

A cohort study of kids with IBD found a similar infection risk associated with the TNF inhibitors infliximab (Remicade) and adalimumab (Humira) — the two approved biologics for this population. (JAMA Network Open)

Delays in starting certain treatments for localized colorectal cancer were linked with a higher risk for metastases. (JAMA Network Open)

Analyses of birth cohorts suggested that early life exposure to per- and polyfluoroalkyl substances (PFAS) — so-called forever chemicals — was associated with intestinal inflammation later in childhood. (Clinical Gastroenterology and Hepatology)

CYP2C19 genotype appears to play a role in how kids with eosinophilic esophagitis respond to proton pump inhibitors. (American Journal of Gastroenterology)

U.K. Biobank data showed that patients with higher levels of intrapancreatic fat deposition had greater all-cause and vascular disease mortality. (American Journal of Gastroenterology)

The British Society of Gastroenterology updated its clinical guidelines for celiac disease in adults. (Gut)

Restarting antiplatelet or anticoagulant therapy within a week of a gastrointestinal bleed reduced major vascular events, despite a higher risk of recurrent bleeds, a meta-analysis found. (Clinical Gastroenterology and Hepatology)

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