Melatonin and Alzheimer’s; Napping-Parkinson’s Link; An Unusual ARIA Case

Could melatonin prevent — or treat — Alzheimer’s disease? A review in Molecular Psychiatry takes a close look.

Exposure to individual metals and mixtures of metals was associated with amyotrophic lateral sclerosis (ALS) diagnosis and survival. (Journal of Neurology, Neurosurgery, and Psychiatry)

Daytime napping frequency was tied to increased Parkinson’s disease risk, but no causal relationship emerged in a Mendelian randomization analysis. (BMC Medicine)

In a JAMA Neurology viewpoint, researchers urged Medicare to cover driving safety assessments for at-risk older adults.

Clinicians described fatal refractory status epilepticus associated with amyloid-related imaging abnormalities (ARIA) in an Alzheimer’s patient treated with aducanumab (Aduhelm). (Neurology)

Mice exposed to air pollution who were fed GSM-15606, an investigational gamma-secretase modulator, had lower levels of amyloid-beta 42. (Alzheimer’s & Dementia)

In another mouse study, non-invasive multisensory gamma stimulation mitigated demyelination. (Nature Communications)

People who run Parkinson’s exercise programs in some cities said it’s difficult to recruit Black patients. (KFF)

The cumulative global incidence of long COVID was estimated at 400 million individuals, with an annual economic cost of $1 trillion. (Nature Medicine)

The FDA approved asleep deep brain stimulation (DBS) surgery with Medtronic’s DBS system to treat Parkinson’s disease or essential tremor.

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