More Lp(a)-Reducing Tx; Cardiac Denervation for Afib; LAA Occluders at 5 Years

Lipoprotein(a), or Lp(a), was successfully reduced in phase II trials of muvalaplin and zerlasiran. (JAMA)

The possibility of a drug interaction between SGLT2 inhibitors and statins was not supported by rates of rhabdomyolysis in a case-control study. (JAMA Network Open)

Among patients undergoing isolated coronary artery bypass grafting, partial cardiac denervation helped reduce the risk of postoperative atrial fibrillation (Afib) in a randomized trial. (JAMA Cardiology)

Five-year results from the Amulet IDE trial suggested similar performance of the Amulet and Watchman 2.5 devices for left atrial appendage (LAA) occlusion in Afib patients. (Journal of the American College of Cardiology)

Users of oral anticoagulants for venous thromboembolism had their bleeding risk more than double when using nonsteroidal anti-inflammatory drugs. (European Heart Journal)

Rivaroxaban (Xarelto) therapy was better taken for 18 months rather than 6 months among patients with cancer and acute low-risk pulmonary embolism, according to a small Japanese randomized trial. (Circulation)

Patients with heart failure due to cardiac sarcoidosis tended to be on better guideline‐directed medical therapy (GDMT) and have a lower risk of adverse cardiovascular outcomes when they participated in a pharmacist‐led medication therapy management program. (Journal of the American Heart Association)

Acute heart failure patients admitted to a “hospital at home” program were able to achieve virtual decongestion and GDMT titration without significant adverse events and little need for care escalation back to a physical hospital. (JACC: Heart Failure)

In a study based on U.K. Biobank data, the amount of ultra-processed foods was higher in vegetarian diets and lower in those with a modest amount of meat or fish. (eClinicalMedicine)

Rural residents have disproportionately high cardiovascular mortality rates, according to research highlighted by the American College of Cardiology.

In donation after circulatory death heart transplantation, agonal periods ≥30 minutes were associated with reduced post-transplant survival and decreased donor heart utilization. (Journal of Heart and Lung Transplantation)