Personalized Breast Cancer Treatment; Insights Into HPV in Men; Exercise and Cancer

Surgical innovations for breast cancer have led to personalized treatment choices that are more complex than lumpectomy versus mastectomy. (Mayo Clinic)

Using a breast cancer’s genetic signature to guide treatment showed promise for improving outcomes in a phase III trial. (The BMJ)

Use of artificial intelligence guidance did not improve the “resect-and-discard” strategy for colonic polyps, a meta-analysis of published studies showed. (Lancet Gastroenterology & Hepatology)

Singer Patti Scialfa, perhaps better known to many people as Mrs. Bruce Springsteen, recently disclosed that she has had multiple myeloma since 2018. (CNN)

Caribbean women with recent breast cancer diagnoses had fewer children and started menstruation (menarche) at earlier ages, according to a study that added to evidence from previous studies. (Sylvester Comprehensive Cancer Center, JAMA Network Open)

New insights into oral HPV infection and cancer risk among men. (Moffitt Cancer Center, Nature Microbiology)

Rigel Pharmaceuticals issued a Dear Health Care Provider letter advising clinicians of a newly identified risk of severe and potentially fatal infections in patients treated with pralsetinib (Gavreto).

Towa Pharmaceutical Europe issued a nationwide recall in the U.S. of the antidepressant/pain reliever duloxetine delayed-release capsules, after tests showed the medication contained unacceptable levels of cancer-causing nitrosamines. (Newsweek)

Observations and insights into the recent uptick in private equity investment in oncology. (Foley & Lardner)

PMV Pharmaceuticals announced discontinuation of enrollment in a phase I trial of its p53-targeting drug rezatapopt plus pembrolizumab (Keytruda) in solid tumors because of dose-limiting toxicities and limited clinical benefit at the maximum tolerated dose.

A study of aerobic exercise in patients with breast cancer showed no effect on objectively measured postchemotherapy cognitive function but a significant association with patients’ own perceptions of cognitive function. (Cancer)

A cancer specialist opens up about the emotional weight of losing a patient. (Oncology News Central)