The indication for sacituzumab govitecan (Trodelvy) in previously treated patients with locally advanced or metastatic urothelial cancer was withdrawn last month after the drug failed to improve survival versus single-agent chemotherapy in the phase III TROPiCS-04 trial.
In light of this changed landscape, Joaquim Bellmunt, MD, PhD, of Dana-Farber Cancer Institute in Boston, discusses second-line treatment options.
Following is a transcript of his remarks:
Sequencing is now an issue because we have now, as mentioned, three options for first-line treatment and the point is what to do next. And then in patients who are receiving chemotherapy followed by maintenance avelumab [Bavencio], after that some patients are receiving enfortumab vedotin [EV, Padcev], and then after that receiving sacituzumab govitecan. That’s the present sequencing on that.
In patients who are receiving EV/[pembrolizumab (Keytruda)], then obviously the most rational next step — and without any data supporting that — we are giving cisplatin because we have not been using the cisplatin in first-line therapy.
Before this ASCO [American Society of Clinical Oncology], another thing that has not been presented is, we heard the press release of the TROPiCS-04, that is the sacituzumab phase III. Unfortunately, this trial was negative. And this is quite concerning because now we were going to have another drug, an ADC [antibody-drug conjugate] sacituzumab govitecan, for sequencing.
Please enable JavaScript to view the comments powered by Disqus.
Source link : https://www.medpagetoday.com/video-coverage/bladder-cancer-video-pearls/112703
Author :
Publish date : 2024-11-01 15:43:57
Copyright for syndicated content belongs to the linked Source.