Steatosis and Cardiovascular Events; Golimumab Biosimilar OK’d; Daily Stress and IBS

Compared to people without liver steatosis, those with the condition had greater noncalcified coronary plaque burden and nearly twice the risk for major cardiovascular events, an analysis of the multicenter PROMISE study showed. (Clinical Gastroenterology and Hepatology)

Hepatitis B and C contribute to roughly three-fourths of the global liver cancer burden, according to a systematic review and meta-analysis. (Gut)

In a randomized trial of mild-to-moderate acute cholangitis, urgent endoscopic retrograde cholangiopancreatography (ERCP) did not reduce mortality or organ failure rates compared with early ERCP. (Gut)

The FDA approved the first interchangeable golimumab (Simponi) biosimilars for treating ulcerative colitis and rheumatoid arthritis.

Ulcerative colitis-associated colorectal neoplasia in younger people was linked with more aggressive histology and worse cancer-specific survival, nationwide data from Japan indicated. (Inflammatory Bowel Diseases)

Is the therapeutic ceiling in inflammatory bowel disease (IBD) a myth? (Lancet Gastroenterology & Hepatology)

Findings from the TRUST BEYOND study offered more support for intestinal ultrasound in routine IBD care. (Inflammatory Bowel Diseases)

Nearly all (98%) kids with IBD showed seroprotection against measles on a high-sensitivity assay, despite 87% being on immunosuppressive therapy, researchers reported in the American Journal of Gastroenterology.

A 12-week course of probiotics did not reduce fatigue in a randomized trial of quiescent IBD. (American Journal of Gastroenterology)

The American Gastroenterological Association has updated guidelines on dealing with Clostridioides difficile infections in IBD. (Gastroenterology)

Meanwhile, Lancet Gastroenterology & Hepatology published a review on the management of colorectal cancer (CRC) in adults 70 and up.

A multimodal prehabilitation program for patients undergoing CRC surgery may reduce complication rates and shorten hospital stays, Dutch researchers suggested. (JAMA Surgery)

More than 12.5 million U.S. women ages 45 to 64 are due for CRC screening, a cross-sectional study estimated. (JAMA Network Open)

Colonoscopy in adults younger than 50 was linked with a 21-26% lower CRC incidence in women and a 38-43% lower incidence in men, claims data from Korea showed. (American Journal of Gastroenterology)

More nonadvanced adenomas brings more risk of advanced colorectal neoplasms, a 20-year analysis of colonoscopies found. (Gastroenterology)

How daily stress is associated with irritable bowel syndrome (IBS) symptoms. (Clinical Gastroenterology and Hepatology)

Evidence that fecal microbiota transplantation can improve IBS symptoms is on shaky ground, a meta-analysis of randomized trials concluded. (Gastroenterology)

Vagal nerve stimulation may ease symptoms of mild acute pancreatitis, according to a randomized study from China. (American Journal of Gastroenterology)