Thursday, August 7, 2025
News Health
  • Health News
  • Hair Products
  • Nutrition
    • Weight Loss
  • Sexual Health
  • Skin Care
  • Women’s Health
    • Men’s Health
No Result
View All Result
  • Health News
  • Hair Products
  • Nutrition
    • Weight Loss
  • Sexual Health
  • Skin Care
  • Women’s Health
    • Men’s Health
No Result
View All Result
HealthNews
No Result
View All Result
Home Health News

Type II Vasculitis Signals Poor Prognosis in Sjögren Disease

August 6, 2025
in Health News
Share on FacebookShare on Twitter


TOPLINE:

Among patients with primary Sjögren disease, type II cryoglobulinemic vasculitis is linked to an increased risk for lymphoma and mortality, a French study showed.

METHODOLOGY:

  • Researchers conducted a retrospective multicenter cohort study of 54 patients with primary Sjögren disease and cutaneous vasculitis (CV) from three pathology departments in Paris and a national case call in France (median age, 42 years; 91% women).
  • Patients were diagnosed with CV between 2011 and 2021; 29 (57%) had cryoglobulinemic vasculitis and 15 (28%) had hypergammaglobulinemic vasculitis; 24 of the 29 cryoglobulinemic cases were type II. Data were analyzed between March 2023 and March 2025.
  • Patients were matched 1:2 to 108 controls with Sjögren disease but without CV from the French ASSESS cohort.
  • Primary outcomes of the study were the occurrence of lymphoma diagnosis and mortality risk.

TAKEAWAY:

  • Patients with Sjögren disease and CV showed a higher lymphoma incidence than those without CV (13% vs 4%; P = .04).
  • Patients with type II cryoglobulinemic vasculitis had a significantly higher incidence of lymphoma (21% vs 0%; P = .02) and increased mortality (29% vs 0; P = .02) than those with other types of small-vessel vasculitis. The risk for death or non-Hodgkin lymphoma was increased by nearly sevenfold risk in patients with type II cryoglobulinemic vasculitis (hazard ratio [HR], 6.8; P = .005) compared with other CV types.
  • Patients with type II cryoglobulinemic vasculitis were more likely to have subacute cutaneous lupus (21% vs 0%; P = .02), kidney involvement (29% vs 4%; P = .02) and peripheral nervous system involvement (63% vs 12%; P < .001) than those with other CV types.
  • Among 24 patients with type II cryoglobulinemic vasculitis, 12 received rituximab-based first-line treatment; non-Hodgkin lymphoma developed in 8% of patients in the rituximab group and in 25% of those who received other treatments, whereas mortality rates were 33% and 25%, respectively.

IN PRACTICE:

“In this cohort study, among patients with CV-complicated Sjögren disease, only type II cryoglobulinemic vasculitis was associated with severe visceral involvement, higher risk of non-Hodgkin lymphoma, and mortality,” the study authors wrote. These findings, they added, highlighted the need for “specific monitoring for these patients.”

SOURCE:

The study was led by Paul Breillat, MD, INSERM, Paris Centre de Recherche Cardiovasculaire, Paris, France, and was published online on August 6 in JAMA Dermatology.

LIMITATIONS:

The retrospective design and potential missing data could affect the interpretation of results. Additionally, half of the patients were diagnosed with CV on the basis of clinical criteria.

DISCLOSURES:

The ASSESS cohort was set up with a grant from the French Ministry of Health. One author reported receiving personal fees from Bristol Myers Squibb, GSK, Novartis, and Otsuka; another author reported receiving grants from AstraZeneca, Bristol Myers Squibb, and GSK. No other disclosures were reported.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.



Source link : https://www.medscape.com/viewarticle/type-ii-cryoglobulinemic-vasculitis-signals-poor-prognosis-2025a1000ktv?src=rss

Author :

Publish date : 2025-08-06 15:05:00

Copyright for syndicated content belongs to the linked Source.

Previous Post

Could RFK Jr’s move to pull mRNA vaccine funding be a huge miscalculation?

Next Post

Air Filters Tackle Elevated Blood Pressure for People Living Near Polluted Roads

Related Posts

Health News

Looming Pay Cut to LAAO Triggers Objection From Card Groups

August 7, 2025
Health News

Genital Ultrasound Crime; Doc Gets 12 Years for Killing Wife; Nurse Impostor Arrest

August 7, 2025
Health News

Americans Get Over Half Their Calories From Ultraprocessed Foods, CDC Report Says

August 7, 2025
Health News

Experts Advise on How to Study DEI in Cancer

August 7, 2025
Health News

CDC COVID Recommendations Debunked; Sugar Cookie Recall; ER Doctor Sentenced

August 7, 2025
Health News

HHS Illegally Withheld NIH Funds, GAO Report Says

August 7, 2025
Load More

Genital Ultrasound Crime; Doc Gets 12 Years for Killing Wife; Nurse Impostor Arrest

August 7, 2025

Americans Get Over Half Their Calories From Ultraprocessed Foods, CDC Report Says

August 7, 2025

Experts Advise on How to Study DEI in Cancer

August 7, 2025

CDC COVID Recommendations Debunked; Sugar Cookie Recall; ER Doctor Sentenced

August 7, 2025

HHS Illegally Withheld NIH Funds, GAO Report Says

August 7, 2025

Major Safety Alert for Defibrillation Leads After Injuries, Deaths

August 7, 2025

Severe AKI Tied to Reduced Survival in Patients on ECMO

August 7, 2025

8 Times Taxpayer Money Led to Historic Leaps in Medical Care

August 7, 2025
Load More

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    

© 2022 NewsHealth.

No Result
View All Result
  • Health News
  • Hair Products
  • Nutrition
    • Weight Loss
  • Sexual Health
  • Skin Care
  • Women’s Health
    • Men’s Health

© 2022 NewsHealth.

Go to mobile version