Omega-3s Linked to Cognitive Decline; Women and Alzheimer’s; Amateur Soccer Heading

Omega-3 fatty acid supplementation was associated with accelerated cognitive decline in older adults, potentially through adverse effects on cerebral synaptic function, data from the Alzheimer’s Disease Neuroimaging Initiative suggested. (Journal of Prevention of Alzheimer’s Disease)

Metrics of sleep-wake cycles were associated with incident dementia and contributed modestly to dementia prediction, an analysis of U.K. Biobank data showed. (JAMA Neurology)

Older women with elevated genetic Alzheimer’s risk and subjective sleep problems had a greater risk for visual memory deficits and tau burden in brain regions affected in early Alzheimer’s disease, a prospective study reported. (Journal of Prevention of Alzheimer’s Disease)

A single MRI scan may help predict Alzheimer’s disease outcomes, models suggested. (Nature Aging)

Heading during a single amateur soccer match was tied to acute increases in blood biomarkers of neural damage in a case-control study. (JAMA Neurology)

Compared with other drugs used for weight management, metformin used alongside antiseizure medication was tied to reduced seizure-related morbidity in epilepsy patients without diabetes, a retrospective analysis found. (Journal of Neurology, Neurosurgery & Psychiatry)

Ambient particulate matter was associated with dementia with Lewy bodies or Parkinson’s-related dementia in a Danish case-control study. (JAMA Network Open)

Pregnant women did not have an increased risk of myasthenia gravis exacerbation in an analysis of Swedish registry data. (Neurology)

The nonprofit advocacy group Public Citizen said the FDA should require warnings about the wakefulness-promoting drugs modafinil (Provigil) and armodafinil (Nuvigil) during pregnancy; some studies have tied the drugs to major congenital malformations in children.