(MedPage Today) -- Immunotherapy-based combinations have rapidly become the dominant first-line treatment for advanced hepatocellular carcinoma (HCC), but real-world outcomes remain heavily constrained by liver function and comorbidity burden... Source...

(MedPage Today) -- The use of bispecific antibodies (BsAb) before chimeric antigen receptor T-cell therapy (CAR-T) appeared to be a more optimal treatment sequence than BsAb after CAR-T in patients...

(MedPage Today) -- In the whirlwind first year of President Donald Trump's second term, some of the most polarizing changes have taken place within HHS, where Robert F. Kennedy Jr....

(MedPage Today) -- Weaker and more fragmented circadian rhythms in older adults were associated with elevated dementia risk, prospective data showed. (Neurology) A meta-analysis found no significant link between menopause...

An image captured by a telescope at the Grasslands Observatory in Arizona. The “x” is where E. E. Barnard saw his mystery starTim Hunter et al. (2025) A star that...

(MedPage Today) -- At the recent American Society of Hematology annual meeting, researchers presented preclinical data examining how transdifferentiation between hematopoietic lineages -- driven by LMO2 expression and p53 loss...

(MedPage Today) -- Over 75% of U.S. adults have obesity under a global Lancet Commission's new definition of obesity, which includes three anthropometric measures along with body mass index. (JAMA...

(MedPage Today) -- Last January, N. Adam Brown, MD, MBA, compared HHS Secretary Robert F. Kennedy Jr. to a broken clock: even he might stumble onto the right answer a...

(MedPage Today) -- Measuring treatment success in Sjögren's disease requires more than tracking systemic disease activity alone. Fatigue, pain, dryness, and daily function often drive patients' quality of life and...

Russia shows off its weaponry at a military parade in MoscowMikhail Svetlov/Getty Images In February 2026, for the first time in decades, there will be no active treaty limiting the...

plainpicture/Michiru Nakayama Lots of science books will be published over the course of the coming year – tonnes, in fact. After spending last month wading through the books and publisher...

travelpixpro/Getty Images Pledging to lose weight is a common New Year’s resolution, particularly after the excesses of the holiday season. In years gone by, that would mean a new January...

Adrian Tchaikovsky’s Children of Strife will be a highlight of MarchJoby Sessions/SFX Magazine/Future via Getty Images I may have to eat my hat later, but I reckon 2026 is shaping...

A marsh deer escaping a forest fire in Poconé, Mato Grosso, in 2020Lalo de Almeida Science Museum How can these four pictures be images of the same region? What force...

Artist’s impression of the BepiColombo spacecraft flying by MercuryESA/ATG medialab We will finally begin to untangle Mercury’s mysteries in 2026, as the BepiColombo spacecraft descend into orbit around the solar...

Valar Atomics’ Ward 250 reactor under constructionDaria Nagovitz/Valar Atomics Despite providing nearly a fifth of US electricity generation, nuclear power in the country has stagnated for decades. Regulatory hurdles, public...

Flocean’s subsea desalination podFlocean Turning seawater into drinking water is so costly and energy-intensive that it’s untenable in most parts of the world, but a Norwegian company is trialling a...

The MMX probe will visit Mars’s moonsJAXA The mystery of how Mars acquired its moons, Phobos and Deimos, may start to be unravelled in 2026 with the launch of a...

Visual China Group via Getty Images In Roald Dahl’s novel James and the Giant Peach, magic crystals cause a withered peach tree to produce a spectacular, juicy, house-sized peach. How...

Russia shows off its weaponry at a military parade in MoscowMikhail Svetlov/Getty Images In February 2026, for the first time in decades, there will be no active treaty limiting the...