Blood Clots After Colonoscopy; Antibiotics and IBS Risk; Can Vitamin D Calm IBD?

Retrospective data showed that resuming direct oral anticoagulants (DOACs) 2 days or more following an elective colonoscopy was linked with a higher risk of thromboembolic events without a reduction in gastrointestinal bleeding, as compared with earlier DOAC resumption. (Clinical Gastroenterology and Hepatology)

Intraoperative use of indocyanine green fluorescence angiography during colorectal resections can reduce anastomotic leaks in rectal and left-sided resections, a systematic review and meta-analysis indicated. (Lancet Gastroenterology & Hepatology)

Researchers suggested that more stool-based tests for colorectal cancer (CRC) screening could save costs and help optimize colonoscopy capacity. (Gastro Hep Advances)

Can blood-based biomarkers ahead of colonoscopy for CRC screening help predict high-risk adenomas? (Gastro Hep Advances)

Antibiotic use for gastrointestinal infections was linked to a 71% higher risk of irritable bowel syndrome (IBS), according to a meta-analysis of more than 30 studies. (American Journal of Gastroenterology)

In a randomized phase II trial of IBS with diarrhea, an investigational partial μ receptor agonist and full κ receptor antagonist (ORP-101) failed to outperform placebo for reducing abdominal pain and improving stool consistency. (Clinical Gastroenterology and Hepatology)

U.S. survey results of people meeting criteria for IBS revealed that men and Black or Hispanic patients were less likely to have received an IBS diagnosis from a healthcare provider. (Clinical Gastroenterology and Hepatology)

Progress to eliminate hepatitis B and C globally is not on track to meet the 2030 targets, according to researchers at the World Health Organization. (Lancet Gastroenterology & Hepatology)

CORE and LiverRisk appeared to be the best routine blood-based tests for predicting severe cirrhosis-related morbidity in the general population, a prospective head-to-head study suggested. (Hepatology)

For patients with liver cirrhosis, a validated machine learning model using available clinical and laboratory data can accurately predict the risk of hepatic decompensation. (American Journal of Gastroenterology)

Arthritis and higher alcohol consumption together at the time of an HFE hemochromatosis diagnosis was associated with an increased risk for liver cancer, researchers reported in Gastro Hep Advances.

Can vitamin D supplementation help restore balance in the gut microbiome of inflammatory bowel disease (IBD) patients? (Cell Reports Medicine)

Researchers in Inflammatory Bowel Diseases detailed how PCR and enzyme immunoassay testing together can tease out the best course for managing patients with IBD and a Clostridioides difficile infection.

Meanwhile, a cross-sectional study of hospitalized cancer patients found that a C. difficile infection increased the risk of in-hospital mortality by 62%. (JAMA Network Open)

Experts in Gastro Hep Advances reviewed the current evidence and treatment implications of a fatty pancreas.