Brain Atrophy and Circadian Rhythms; New Fluoride and IQ Data; Autism Brain Donation

Weaker, more fragmented circadian rest-activity rhythms in cognitively healthy adults were tied to smaller medial temporal lobe volumes, cross-sectional data showed. (Alzheimer’s & Dementia)

Plasma phosphorylated tau 217 (p-tau217) predicted the progression of amyloid PET scan changes and cognitive decline in healthy older people, according to longitudinal data from the Harvard Aging Brain Study. (Nature Communications)

Loneliness affected memory in older adults but did not accelerate brain decline, data from a European longitudinal cohort suggested. (Aging & Mental Health)

Fluoride in drinking water had no effect on IQ or brain function, according to a long-term study. (PNAS)

A large U.S. study reported that family resilience was associated with lower odds of depression in children with traumatic brain injury. (JAMA Network Open)

Patients who had surgery for chronic subdural hematoma had excess mortality and self-reported cognitive and functional impairments, a 10-year Swiss study showed. (JAMA Neurology)

An Autism BrainNet survey revealed that while most Americans support autism research, 70% had not heard of brain donation, suggesting a limited understanding of postmortem brain studies.

Electrical stimulation of corticostriatal circuits appeared to mitigate self-injurious behavior in an autism mouse model and may have benefit for some children, a small study suggested. (Science Advances)

Thymectomy appeared to be cost-effective for non-thymomatous myasthenia gravis in the U.K. National Health Service, according to an economic evaluation. (JAMA Network Open)

The U.K. Biobank, a growing source for dementia research, is now 20 years old. (Nature Reviews Neurology)

No Doubt guitarist Tom Dumont revealed his early-onset Parkinson’s disease diagnosis. (USA Today)

Actress Selma Blair, who was diagnosed with multiple sclerosis in 2018, said she’s relapse-free. (The Independent)