Fart Frequency in Men vs Women; Organ Transplant in Celiacs; Engineered Gut Bacteria

Using the Chart Your Fart app, Australians self-reported an average of five flatus per day, with a higher number recorded among males versus females, at 5.2 versus 4.8. (JAMA Network Open)

First-in-class miR-124 enhancer obefazimod for ulcerative colitis met the primary endpoint of clinical remission in the phase III ABTECT maintenance trial, drugmaker Abivax announced, but data also showed more cancers in the obefazimod arms.

In first-degree relatives of people with Crohn’s disease, intake of the dietary fibers β-glucan and inulin was associated with preserved gut barrier function and lower Crohn’s disease risk. (Gastroenterology)

A meta-analysis identified infliximab (Remicade) as an effective option for perianal fistulizing Crohn’s disease but found limited evidence of benefit with other advanced therapies. (Inflammatory Bowel Diseases)

Chronic opioid use in inflammatory bowel disease patients was linked with higher risks for infection and mortality, a Denmark study found. (Inflammatory Bowel Diseases)

Celiac disease was associated with a nearly threefold higher risk of organ transplant, in particular liver transplant, in a study from Sweden. (Clinical Gastroenterology and Hepatology)

A brief report showed the promise of preemptive anticraving therapies given soon after liver transplant for patients with alcohol-associated liver disease. (Liver Transplantation)

A European study of repeated liver stiffness measurements suggested that screening for liver fibrosis is best targeted to high-risk individuals, such as people with obesity or diabetes, harmful alcohol use, or elevated alanine aminotransferase levels. (Lancet Gastroenterology & Hepatology)

The FDA accepted a letter of intent for an artificial intelligence-based tool to help predict drug-induced liver injury during small-molecule drug development.

In an Italian study of hepatocellular carcinoma patients with tumoral portal vein thrombosis, transarterial Y90-radioembolization downstaged 25% of the patients to liver transplant eligibility. (Hepatology)

Under real-world conditions, co-testing for Helicobacter pylori stool antigen amid fecal immunochemical test (FIT)-based colon cancer screening proved more cost-effective than FIT alone, a Taiwan study found. (JAMA)

An engineered 15-strain gut bacteria product could be a more scalable alternative to fecal microbiota transplants for patients with recurrent Clostridioides difficile infection, a phase Ib study suggested. (Nature Medicine)

Regular physical activity was independently associated with a lower risk for chronic pancreatitis, U.K. Biobank data showed. (Gut)

Pregnant women with a history of pancreatitis faced higher risks for adverse outcomes, including gestational diabetes or hypertension, preterm birth, and C-section, research from Norway indicated. (Gastro Hep Advances)