New Heart Failure Definition; Mitral TEER Pitfalls; Drug’s Comeback in Stroke?

International groups agreed on a second universal definition of heart failure, which moves away from rigid ejection fraction cutoff values. (Journal of the American College of Cardiology)

AC01, a novel oral calcium-sensitising inotrope and ghrelin receptor agonist, showed promise for heart failure with reduced ejection fraction in a phase Ib/IIa study. (The Lancet)

Researchers unveiled the HeartMap, an atlas of 2.4 million cells from healthy and diseased hearts. (Nature Cardiovascular Research)

Untreated mild hyperglycemia was tied to hypertensive disorders of pregnancy, according to a retrospective analysis. (Journal of the American Heart Association)

Abbott announced that real-world outcomes from the TVT registry backed TriClip transcatheter edge-to-edge repair (TEER) for reducing tricuspid regurgitation, and the Navitor transcatheter aortic valve implantation system for patients with small aortic annuli. (Mass Device)

Compared with surgical mitral repair in younger patients, mitral TEER was associated with substantial institutional variability and worse valve-related outcomes in a retrospective study. (Annals of Thoracic Surgery)

The FDA cleared the Ecliptis left atrial appendage exclusion clip to prevent blood clots in patients with atrial fibrillation.

An early feasibility study supported transcatheter aortic valve replacement (TAVR) with the J-Valve for high-risk patients with severe aortic regurgitation. (JSCAI)

With the ShortCut leaflet splitter in commercial use, valve-in-valve TAVR was associated with few coronary obstructions in patients with elevated risk. (JACC: Cardiovascular Interventions)

After left atrial appendage closure, same-day discharge was not linked to higher rates of early readmission, according to a national database analysis. (Structural Heart)

Inflammation may modify the risk of cardiovascular disease associated with lipoprotein(a), a primary prevention cohort study suggested. (JAMA Cardiology)

For stroke patients undergoing endovascular therapy, nerinetide was associated with improved 1-year outcomes despite having failed to show a neuroprotective benefit at 90 days in the ESCAPE-NEXT trial. (Journal of the American Heart Association)

A proteomics and metabolomics analysis identified new biomarkers for cardiotoxicity from breast cancer therapies. (European Heart Journal)

Good cardiovascular health and wide social networks were both important for longevity, a Korean study found. (European Journal of Preventive Cardiology)