Push for Cath Lab Safety; Eplontersen Flops in ATTR-CM; Off-Label Testosterone Risks

A multisociety expert consensus statement calls for wider implementation of enhanced radiation protection devices for cath lab operators. (JACC: Cardiovascular Interventions)

The FDA approved Johnson & Johnson’s Dual Energy Thermocool Smarttouch SF Platform, a radiofrequency and pulsed field energy catheter ablation system.

The world’s first documented single-port robotic mitral valve repair surgery took place at Corewell Health in the Detroit area.

In a randomized noninferiority trial, the YEARS diagnostic algorithm was as safe as a CT pulmonary angiography approach for ruling out acute pulmonary embolism in patients with active cancer. (JAMA)

Among patients with cancer-associated thrombosis on extended apixaban (Eliquis) after at least 6 months of anticoagulation treatment, recurrent blood clots were uncommon but associated with poor short-term survival, according to a post-hoc analysis of the API-CAT trial. (Circulation)

Mesoglycan had mixed results for secondary prevention of superficial vein thrombosis of the legs, a phase II trial suggested. (eClinicalMedicine)

A Dutch trial found that lower anticoagulation targets in extracorporeal membrane oxygenation may be similar to standard doses. (The Lancet)

Eplontersen (Wainua) failed to meet its primary efficacy endpoint of a composite of cardiovascular mortality and recurrent cardiovascular events in the phase III CARDIO-TTRansform trial of patients with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM), Ionis Pharmaceuticals and AstraZeneca announced.

In FINEARTS-HF, finerenone (Kerendia) showed blood pressure-lowering effects in patients with heart failure with mildly reduced or preserved ejection fraction. (JAMA Cardiology)

Off-label testosterone therapy in men without evidence of hypogonadism was linked to cardiovascular risks out to 10 years, according to a retrospective real-world cohort study. (eBioMedicine)

The American Heart Association had soccer fans practice more than 800,000 CPR training compressions across four cities hosting the FIFA World Cup.

A New York student-athlete diagnosed with Wolff-Parkinson-White syndrome is now an advocate for community ECG screening. (New York Post)

Flu vaccines were associated with lower risks of incident atrial fibrillation and multiple cardiovascular outcomes in a target trial emulation study based on retrospective data. (European Heart Journal)

A line between hypertension and oral health could be drawn in older Chinese adults, a cross-sectional study suggested. (Clinical Cardiology)

Cardiac MRI had clinical utility in the diagnosis of pericarditis, according to a retrospective analysis. (Heart)

The oral NLRP3 inhibitor ruvonoflast will be tested in a phase II study after preliminary data suggested that it significantly reduced high-sensitivity C-reactive protein and other inflammatory biomarkers in participants with high atherosclerotic cardiovascular disease risk. (Journal of the American College of Cardiology)