Red Wine and Bowel Disease; Transplant Paper Retracted; AGA Dumps on CRC Blood Test

A study in Gut found that red wine may be associated with a lower risk of inflammatory bowel disease (IBD).

But drinking roughly two alcoholic beverages a day was linked with a 10% to 30% higher risk of pancreatic cancer, a meta-analysis of cohort studies concluded. (International Journal of Alcohol and Drug Research)

The Journal of Hepatology retracted a 2014 paper on liver transplantation in China after concerns were raised the organs involved may have been procured unethically.

Among adolescent liver transplant recipients, a novel electronic health record-based marker can spot nonadherence to immunosuppressive medications and trigger interventions to help prevent organ rejection. (American Journal of Transplantation)

Data from the INSPPIRE cohort found that 74% of kids with pancreatitis had a genetic risk variant. (Clinical Gastroenterology and Hepatology)

HLA-DRB1*01:03 is a genetic marker of severe disease across IBD phenotypes and could identify patients for early aggressive treatment, according to a study in Lancet Gastroenterology & Hepatology.

An investigational anti-TL1A antibody met its primary endpoint in a phase II study of moderate-to-severe ulcerative colitis, Spyre Therapeutics announced.

Studies out of Asia flagged leucine-rich alpha-2 glycoprotein and fecal butyrate concentration as useful biomarkers for monitoring treatment response in Crohn’s disease and ulcerative colitis, respectively. (Inflammatory Bowel Diseases)

GLP-1 drugs are no help for improving IBD-related outcomes among patients with stable IBD, a target emulation trial suggested. (Clinical Gastroenterology and Hepatology)

Can switching to a whole food diet reduce intestinal inflammation in subclinical Crohn’s disease? (Clinical Gastroenterology and Hepatology)

Meanwhile, a small randomized trial showed that a low FODMAP diet can improve symptoms in postprandial functional dyspepsia. (Clinical Gastroenterology and Hepatology)

As a blood test makes its way into colorectal cancer (CRC) screening guidelines, the American Gastroenterological Association (AGA) said colonoscopy remains the “strongest option.”

Hong Kong’s launch of a heavily subsidized population-wide CRC screening program was linked with higher screening rates and fewer disparities, researchers reported in JAMA Health Forum.

Experts in JAMA unpacked the rise in early-onset CRC.

A study in Gastroenterology proposed refining the indicators for liver fibrosis screening to capture a higher-risk population.

Gamma-glutamyl transferase, older age, cirrhosis, and detectable hepatitis D virus RNA were flagged as predictors of liver-related outcomes in a contemporary European cohort of chronic hepatitis D patients. (Gut)