GLP-1s and Chronic Pancreatitis; Hypoglycemia After Bowel Prep; Lower GI Bleeding

A real-world study of chronic pancreatitis found GLP-1 agonists to be associated with less pain medication use and lower risks for pancreatic interventions, including major surgery. (Gastro Hep Advances)

The FDA expanded the approval of linaclotide (Linzess) to include the treatment of functional constipation in children 2 years and up, drugmaker Ironwood Pharmaceuticals announced.

Kids and young adults undergoing bowel preparation for colonoscopy had an increased risk of hypoglycemia, a retrospective study found. (American Journal of Gastroenterology)

U.S. survey data revealed practice differences in Clostridioides difficile infection management between gastroenterologists, infectious disease specialists, and primary care doctors. (Gastro Hep Advances)

Imdusiran, an investigational small interfering RNA therapeutic in development as a potential functional cure for chronic hepatitis B, demonstrated safety and tolerability in a phase I trial. (Lancet Gastroenterology & Hepatology)

Authors in the American Journal of Gastroenterology discussed how to communicate drug-related risks in ulcerative colitis and Crohn’s disease.

A multidisciplinary group of experts issued recommendations on the use of intestinal ultrasound to detect Crohn’s disease recurrence after surgical bowel ileocolic resection. (Lancet Gastroenterology & Hepatology)

A look at the management of cutaneous Crohn’s disease. (JAMA Dermatology)

Combined induction therapy with vedolizumab (Entyvio) and upadacitinib (Rinvoq) led to higher remission rates in ulcerative colitis versus vedolizumab alone, findings of a randomized open-label trial in China suggested. (Clinical Gastroenterology and Hepatology)

Most patients with chronic pouchitis reduced their antibiotic use after starting advanced therapies. (Inflammatory Bowel Diseases)

Deep-learning algorithms could help improve early esophageal squamous cell carcinoma detection and outperformed junior endoscopists, a systematic review and meta-analysis indicated. (American Journal of Gastroenterology)

Rates of guideline-recommended liver cancer surveillance for patients diagnosed with cirrhosis haven’t recovered from the steep drop-off that followed the COVID pandemic, a U.S. analysis of safety-net health systems suggested. (JAMA Network Open)

The Oakland score may be the best among risk scores for helping identify emergency department patients with lower gastrointestinal bleeds who can be safely discharged. (Clinical Gastroenterology and Hepatology)

A Danish register-based study of ventral hernia repair revealed higher reoperation risks for recurrence or bowel obstruction with either retromuscular or intraperitoneal onlay mesh placement versus onlay mesh placement. (JAMA Surgery)

A new common definition and unified framework for diagnosing porto-sinusoidal vascular disorder (PSVD) or noncirrhotic portal fibrosis (NCPF). (Hepatology)

Adults with steatotic liver disease in a safety-net health system cited costs and a lack of motivation or knowledge about healthy cooking as barriers to healthy eating. (Gastro Hep Advances)

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