How the Brain Works at Night; An Unusual ARIA Case; Smartwatch Detects Seizures

A review in Science looked at the oscillatory biology of sleep and how disruptions are linked with dementia risk.

Using artificial intelligence (AI) and MRI data, a novel framework revealed how the brain clears out waste at night. (Science Advances)

Aging and the APOE4 gene appear to induce neuroproteasome loss leading to Alzheimer’s disease. (Nature Neuroscience)

A case report described a 75-year-old woman who had a rare presentation of amyloid-related imaging abnormalities (ARIA) with profound hyperactive delirium and myoclonic movements after an infusion of donanemab (Kisunla) for early Alzheimer’s. (Cureus)

The brain of former NHL player Claude Lemieux, who died by suicide last week, is being donated to the Boston University CTE Center to research the long-term effects of repetitive brain injuries. (AP)

Higher doses of ocrelizumab (Ocrevus) did not further improve disability progression in either relapsing multiple sclerosis (MS) or primary progressive MS, the phase IIIb MUSETTE and GAVOTTE trials showed. (The Lancet)

Earlier this year, China approved the world’s first invasive brain-computer chip for use beyond clinical trials. MIT Technology Review looked at what’s next.

A smartwatch app accurately detected tonic-clonic seizures in people with epilepsy, with a low rate of false alarms. (Neurology Open Access)

An ultra-brief intermittent theta-burst stimulation protocol was an effective alternative to standard high-frequency repetitive transcranial magnetic stimulation for treating depressive symptoms in Parkinson’s disease, a randomized trial in China found. (JAMA Network Open)